Dr. Bowen has developed and is now using two new tools to improve results of regenerative medicine procedures at The Center: HI-DEF™ (density enhanced fraction) platelet concentrate and HEAL™ (high efficiency adipose lipoaspirate). These new methods offer an improvement over earlier techniques of processing a patient’s blood to produce a platelet concentrate and of processing a patient’s fat (adipose tissue) to concentrate adult stem cells.
Both platelet concentrate (or platelet rich plasma – PRP) and adipose-derived adult stem cells are being used in cosmetic regenerative medicine applications such as autologous (your own) fat transfer from areas of excess such as the abdomen, “love handles,” hips, or thighs to areas of deficiency such as the face, hands, breasts, or buttocks. There are also orthopedic applications including treatment for arthritis and cartilage and tendon injuries. Other applications currently in the investigational stage include possible treatments for congestive heart failure, diabetes, COPD, and wound healing.
Platelets contain growth factors, which are released after an injury to initiate a healing response. This response can be amplified by using an increased concentration of the patients’ own platelets. Currently available equipment for preparing PRP increase the platelet concentration by a factor of 1.5 to 2.5 times that found in whole blood. Dr. Bowen’s HI-DEF™ technique increases the platelet concentration by a factor of 4 to 5 and therefore increases the quantity of healing growth factors available. This improves upon previous platelet concentration methods that also allowed white and red blood cells to mix with the growth factors, thus resulting in an increase in the inflammatory response including increased bruising and swelling of the treated area.
Previous methods of harvesting, processing and using autologous fat have had unpredictable results due in part to the loss of adult stem cells during processing. At The Center, improvement of this technique was achieved by isolating adult stem cells by an enzymatic process. This, however, requires special lab equipment and expertise and is not readily available in other facilities. The HEAL™ technique concentrates the adult stem cells by using just a centrifuge, which allows a faster and therefore less expensive procedure. This procedure could be duplicated in many other facilities making this technology available to a much larger population.